The Department of Dermatology for Westmead Hospital has a strong emphasis on medical education, especially increasing dermatology knowledge in medical students and nurturing and recognising those with a talent in dermatology. With over 20% of GP presentations being skin related, it is important that all clinicians have a solid understanding of cutaneous pathologies. The department therefore holds a monthly online quiz on a variety of common dermatological conditions which is made available to Stage 3 students in the Westmead Clinical school. This year, the winners the Dermatology Prizes were Joseph Joseph and Damien Le.

Joseph Joseph won the 2018 Best Student in Dermatology Award - he achieve perfect attendance during his dermatology rotation and scored the highest in the monthly dermatology Quiz. Damien Le won the 2018 First in Dermatology Monthly Quiz Award - in recognition of his excellent scores in the dermatology monthly quiz, despite not having a dermatology placement.

Congratulations to the two winners! Please stay tuned for the onset of the Dermatology Monthly quiz in 2019!

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The Department of Dermatology at Westmead Hospital offers a 1-year Oncodermatology training program currently open for recruitment. The program will commence in August 2019, and includes clinical work in Melanoma, High-Risk Melanoma, Non-melanoma skin cancer, Cutaneous Lymphoma, Cutaneous Effects of Oncology Treatments, Oncodermatology triage clinic, Locally Advanced and Metastatic BCC, Radiation Oncology, Graft versus Host Disease, and Dermatological Surgery (under supervision of a plastic surgeon). The candidate will be involved in Multidisciplinary care of patients with Melanoma and Cutaneous Lymphoma, and in the supervision of Medical Research Fellows working in the Oncodermatology clinics. There is training in full body photography and sequential digital dermoscopy and confocal microscopy.The Oncodermatology Fellow participates actively in the weekly Dermatopathology meeting. The program could be complemented with a rotation at the Melanoma Institute of Australia and The Skin Hospital.

This is an Honorary (unpaid) position and candidates should demonstrate to have funding for the whole year. There is no fee for the training. The position will work at Senior Registrar level. Overseas applicants require high level of English language (see requirements in AHPRA), and Westmead Hospital will help the candidate to obtain medical registration (AHPRA, https://www.ahpra.gov.au) and working/study visa (usually a Training visa subclass 407, https://www.border.gov.au).

The Department of Dermatology at Westmead Hospital is a tertiary level, specialized Dermatology unit that serves an area of 1.2 million people from Western Sydney and Nepean Blue Mountains Local Health Districts (NSW, Australia), and provides inpatient, outpatient and consulting services. Our outpatient clinics include General Dermatology Clinics, Procedure clinics, and specialised clinics (ie, Transplant, Cutaneous Lymphoma, Graft-versus-Host Disease, Advanced Surgery, Severe Psoriasis, Severe Eczema, Hidradenitis Suppurativa, High Risk Melanoma and Oncodermatology). Our technologies include Full Body Photography, Sequential Digital Dermoscopy, and Confocal Microscopy. Westmead Hospital is a teaching Hospital for the Sydney Medical School (The University of Sydney) and our Department is an Accredited Centre for Dermatology training of the Australasian College of Dermatologists. We provide dermatology training to more than a 100 Medical Students and 6 Registrars each year, and have a number of teaching activities, including weekly tutorials and monthly meetings.

If interested please email your CV with a covering letter to:
WSLHD-WM-Dermatology-Secretary@health.nsw.gov.au

Closing Date: Friday 15th of December 2018

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The Australasian Dermatopathology Society's Annual Meeting in Adelaide is a truly fantastic conference which brings together dermatologists and pathologists. The conference, held annually in September, shows off the newest findings in dermatopathology and interesting cases with useful clinical implications. The conference is a local favourite amongst many dermatologists and registrars.

Dr Rose Liu, a research fellow from Centre for Translational Skin Research presented on her research regarding BAP-omas, a recently described melanocytic tumour. Dr Liu's enlightening poster attracted many readers as BAP-oma is a relatively new entity. Dr Cathy Zhao, also a member of Centre for Translational Skin Research presented her research regarding the immunohistochemistry profiles of basal cell carcinomas in patients anti-PD1 therapy. The study found BCCs are less likely to develop under anti-PD1 due to PD1/PDL1 blockage. Forturnately, Dr Zhao was awarded the Brenan Prize for the best paper presented by a registrar.

Our team members also really enjoyed the relaxing atmosphere of Adelaide with its beautiful hills and delicious cafes.

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On October 6, 2018 a Dermatology Skills Workshop was organized at Westmead Clinical School, an introductory and practical event about Dermatology for medical students. The workshop featured 3 stations about dermoscopy, skin biopsies and histopathology/cultures. Dr Linda Chan (Research Fellow), Dr Rose Liu (Research Fellow) and Dr Peru Urigoitia Ugalde (Dermatologist & Oncodermatology Fellow) from the Department of Dermatology at Westmead Hospital presented the lectures. Students had the opportunity to learn in a practical way different skills employed in Dermatology: how to use a dermatoscope, how to do punch biopsies/excisions/sutures and how to take swabs for cultures.
Students showed great interest and we've heard positive feedback from the organisers. We will do this event again next year.

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Recently, Ali Azimi had the privilege to attend the 22nd International Mass Spectrometry Conference (IMSC2018), in Florence, Italy.

"The IMSC is the largest international conference on mass spectrometry and allied topics with a history of more than fifty years. The venue of the conference which was held from 25-31 August 2018 was the historic "Fortezza da Basso", a masterpiece of Renaissance military architecture, built in 1534-1537.
The IMSC2018 had brought together a broad spectrum of scientists and mass-spectrometrist from across the globe. Hundreds of presenters presented their works in the forms of oral or poster on topics ranging from recent developments in the area of mass spectrometry techniques to the application of these technique in new fields of research including cancer. It was impressing to see the vast amount of mass spectrometry-based researches happening across the globe.
My contribution to the conference was to firstly present my work describing the efficient and non-invasive method of Tape Stripping (TS) for the collection and extraction of proteins from the stratum corneum of patients with actinic keratosis and its use for subsequent diagnostic biomarker analysis using mass spectrometry-based proteomic techniques. My second presentation at the IMSC2018 described proteomic investigation of actinic keratosis, Bowen’s disease and cutaneous squamous cell carcinoma using the SWATH approach. The presentations were well-received by the audiences in the conference and led to some good discussions with other researchers. While my works involved unique approaches in studying non-melanoma skin lesions at the protein level, equally it was exciting to see how other researchers have used different mass spectrometry techniques for molecular profiling studies of different cancers which could be adopted in skin cancers as well.
I found that, among others, lipidomics, and proteomic studies of different lesions using the MALDI imaging mass spectrometry (MALDI-IMS) were highly noticeable. In MALDI imaging, matrix-assisted laser desorption ionization is used to move a thin tissue section in two dimensions while recording the mass spectrum. The advantage with this technique is that it measures the distribution of a large number of analytes at one time without destroying the sample. A study presented by another group at the IMSC2018 attempted to use this technique for molecular profiling of skin samples. Majority of the molecules, although not many, the researchers had measured in the stratum corneum and epidermis layers were mainly lipids and other metabolites. In their studies, a number of proteins and lipids were measured in the dermis layer of the skin. With further improvements and optimisation studies, MALDI-MS has great potential for molecular profiling studies of skin cancer lesions, especially the small lesions where collecting sufficient material for LC-based mass spectrometry is a limiting factor.
In addition, lipidomics which is a subset of metabolomics, is an emerging field in biomedical research. Lipidomics is the large-scale study of pathways and networks of cellular lipids in biological systems. While genomic and/or proteomic studies alone or when combined, provide useful information about the behaviour of cancer lesions at the molecular level, but they don’t provide a complete understanding of the lesions. Lipids play important roles in cellular functions including cell proliferation and cell death since they are involved in chemical-energy storage, cellular signalling and cell–cell interactions. Interestingly, at IMSC2018, AB Sciex presented one of their recent works involving the application of SWATH acquisition method for a comprehensive lipidomic studies of human samples. Our team is already utilising the SWATH-proteomic technique in melanoma and non-melanoma skin cancers. The application of multi-omics approaches towards cancer lesions which include genomics, proteomics (including phosphoproteomics) and lipidomics will surely provide a better understanding of the disease, aiding diagnosis and effective therapeutic interventions.
My travel to attend the IMSC2018 was funded by the International Mass Spectrometry Foundation (IMSF) Nico Nibbering Travel Award and the Australian and New Zealand Society for Mass Spectrometry Travel Award. We are thankful for their generous support which surely enriched my experience with more information, knowledge and confidence

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At Westmead Hospital, we will be having our World Psoriasis Day Community Forum as we have been doing since 2010. This time will be on the 25th of October at 6:00 pm (with some food available from 5:30 pm). The World Psoriasis Day theme for 2018 is "Treat Psoriasis Seriously, Our Lives Depend On It” and it is all about managing appropriately all aspects of the disease, not only the skin.

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Today, with more than 40 cancer immunotherapy indications and over 2,000 clinical trials, immunotherapy has become all but cemented in the future oncological treatment. It is therefore of upmost importance that clinicians are able to recognise and manage cutaneous toxicities - the most common immune related adverse event.

We would like to invite dermatologists, medical oncologists, registrars, advanced trainees, interested BPTs, nurses, and any other medical practitioner in joining us for a morning of education on the practicalities of diagnosing and treating skin effects of anti-cancer therapies - from targeted and immuno-therapies to classic chemotherapy.

Skin Effects of Systemic Anti-Cancer Therapies
Department of Dermatology, Westmead Hospital
When: Saturday 24th of November 2018. Registration begins at 8.30am.
Where: Case Study Room, Westmead Education and Conference Centre, Level 1, Westmead Hospital.

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